It took a while but the first real plant-specific Full-Spectrum CBG extracts from the Cannabis plant are a fact. This means a full-fledged cannabis plant, rich in Terpenes and flavonoids, and with hardly any THC percentage in the plant.
Completely developed, grown and produced by CBD Spain Medicinal Food SL
<0.05% THC in the Flower
After years of breeding, we have developed a few interesting pure CBG strains, including the “ G5 ” with 7% CBG and the “ Asklepios ” 12% CBG and 0.0% THC in the buds.
The ”G5” and the “ Asklepios ” are both suitable for both indoor and outdoor cultivation. The plants can be planted outside in Spain in mid-May, depending on the time of day and conditions, we need two to three thousand clones per hectare.
In the greenhouses one should count on four clumps per square meter, but only when possible be darkened. When you can darken in the greenhouse in a professional manner, then you can harvest more than 5 times a year.
The flowering time of the “G5” is 48 days and the “Asklepios” 65 days, they produce nice fat flower buds full of Cannabinoids, Terpenes and Flavonoids.
The CBG cannabis plants that are grown outside organically are naturally so resistant itself, that spider mites, lice and other insects leave the plants alone. Caterpillars can do one become a problem, especially when the buds are almost ready.
In short, beautiful, strong, resistant and scientifically very interesting pure CBG cannabis plants.
Since, for scientific reasons, we only grow our strains using balls, that’s because you then almost always have the same chemical composition.
In other words, clones originating from one carefully selected mother plant are guaranteed uniform cannabis extracts, year after year,
If one were to grow from seeds, that would be a completely different story, each seed is its own individual with its own chemical composition.
To obtain a uniform Full-Spectrum Cannabis Extract, the use of clumps is very desirable.
The test results of the “ G5” 7.0% CBGa 0.3% CBDa and <0.05% THC tot.
“ Asklepios” 12.0% CBGa 1.7% CBDa and 0.06% THC tot.
The pure extraction of the G5 Bio mass (naturally dried in two weeks) is crystal clear, saffron colored and very fruity scent.
CBG is in the same boat as CBD, but with even less research on the efficacy and less availability. Still, proponents believe the substance is one Viable alternative treatment option may be for people with diabetes anxiety and chronic pain, maybe even better than THC and CBD
CBGo the MOTHER of all Phytocannabinoids
CBGa is the precursor to all other cannabinoids that are found in the cannabis plant found. It is often considered a mother cannabinoid because there without CBGa no other cannabinoids would exist.
CBGa is formed when geranyl pyrophosphate and olivetolic acid, two organic compounds present in the cannabis plant are combined.
It is an important building block in cannabinoid formation, including CBDa, THCa, CBCA and CBG.
The plant’s trichomes act as a protective function for cannabis and produce CBGa, which targets plant cell necrosis for natural leaf pruning. Through this action allows the plant to maximize the energy directed to the flower.
CBGa is actually the basis of the cannabis flower. It’s at the top of the cascade reaction that produces the three main cannabinoid lines:
THCA (tetrahydrocannabinoleic acid), CBDA (cannabidiolic acid) and CBCA (cannabichromenic acid). Ultimately these become THC, CBD and CBC respectively.
CBGa can also be converted into CBG, but in most species it becomes CBGa eventually converted into CBDa or THCa.
What are the effects of CBG
Like any other cannabinoid, CBGa has the ability to integrate with the endocannabinoid system and provide essential stimuli to the human body. The results obtained from the experiments that are on this molecule are numerous. They are still definitely uncertain, but it is certain that CBG is in the scientific future will be of great importance.
The studies conducted so far attributed him the ability of tumor growth inhibitor, that of neuroprotector, appetite stimulant, suppressant of auto immune and immune responses. Another critical moment when scientists concentrated a lot is that of pain relief. It appears that CBG de can inhibit transmission of painful and inflammatory stimuli to the brain very effective as a pain reliever and also acts as an anti-inflammatory. Moreover it appears that CBG is the CB1 and CB2 receptors of the endocannabinoids system and thus affects the central nervous system. It can be different achieve results, such as combating the terrifying states, which possibly caused by THC and its psychotropic effects, and may also have antidepressant-like implications.
The benefits of CBG.
Research into the effects of CBG is still early, but there are already a number of interesting ones research with these new cannabinoids.
CBG provides powerful anti-anxiety effects
One of the driving factors behind the rising popularity of CBG products is it effect on anxiety. Some experts even suggest that CBG is more reliable for controlling anxiety than CBD.
CBG blocks the psychoactive effects of THC
CBG itself is not psychoactive at all. This means that no matter how much you take, you will not feel high on it.
But it goes one step further.
CBG can also counteract the psychoactivity of THC – the active ingredient that is responsible for the high induced by using marijuana.
THC also directly activates two specific serotonin receptors – known as 5HT1A and 5HT2A. Both receptors are directly involved in changes in perception, mood and various other biological processes (such as heart rate, blood pressure and body temperature).
CBG has been shown to block many of the psychoactive effects of THC by binding and tearing the CB1 receptors and the 5HT1A serotonin receptors to block. This explains why marijuana strains harvested too early (higher CBG values) are much less potent than marijuana flowers that are allowed to ripen.
Some people combine CBG extracts or CBG rich flowers with marijuana limit the psychoactive side effects.
CBG can improve glaucoma
The Endo cannabinoid system plays a vital role in the health of it eye. There is a dense concentration of Endo cannabinoid receptors in the eye tissue, responsible for maintaining the health of this sensitive organ. This is one of the reasons cannabis products are so effective in sustaining of eye conditions such as glaucoma.
A Polish study published in 2008 clearly showed that CBG one of the main powerhouses of cannabis was the one that created a reduction in intraocular pressure associated with glaucoma.
This ability to lower intraocular pressure is thought to be the result of the potent vasodilating (blood vessel widening) effects of CBG.
This effect is important because other studies have shown that CBD itself is not effective treatment for glaucoma, forcing patients use psychoactive cannabis products. Lots of people who have cannabis products are not interested in getting high and see this as negative. Now, with CBG, patients may be able to get relief from glaucoma without the psychoactive ones side effects.
… Is a condition in which nerve cells in the brain are broken down. In a 2015 study investigated the possible neuro-protective properties of CBG and other cannabinoids in mice with disease
Huntington. It was noted that CBG acted as a neuro-protectant and the protects nerve cells in your brain from damage. It also improves motor deficits and preserves striatal neurons against 3-nitropropionic acid poisoning.
CBG is a promising anti-cancer agent
Several cannabinoids have been linked to elevation in the past survivability of cancer. While much of this research has focused on THC and CBD, there are also other studies underway on some of the new cannabinoids
In 2014, a study looked at the anti-cancer potential of CBG for colon cancer cell lines (carcinoma). The study found that CBG helps with colon cancer growth mice.
Researchers in this study suggested that it is the primary anti-cancer benefit of CBG was the result of the ability to inhibit a receptor in our cells is known as TRPM8 (Transient receptor potential cation channel subfamily M). This one receptor is commonly referred to as the “menthol receptor” because it is used to treat cause a “cooling” feeling of menthol.
TRPM8 is important because it is involved in the growth, proliferation and survival of certain cancer cell lines. Blocking this channel is one of the most important research areas for the development of new anti-cancer drugs.
Specifically, TRPM8 is involved in the following cancer types:
- Adeno carcinoma (breast, colon, lung, pancreas and prostate cancer) • Lung carcinoma
- Melanoma (skin cancer)
- Urinary bladder carcinoma
- Glioblastoma multiforme (brain cancer)
- Oral squamous cell carcinoma (mouth cancer)
- Osteo sarcoma (bone cancer)
The colon cancer research also suggested that CBG had an inhibitory effect on colon cancer due to its powerful anti-inflammatory effect profile that is specific for the colon. Studies have shown chronic inflammation in the colon and the upper digestive tract was related to the development of colon cancer.
CBG has antibacterial properties
Several studies have been done on the antibacterial properties of it cannabis derivatives.
All five primary cannabinoids produced by cannabis (THC, CBD, CBG, CBC and CBN) have potent inhibitory effects on drug resistant drugs strains of staph bacteria.
CBG in particular appeared to work by increasing the permeability of the bacterial cell wall reduce – increasing the ability to obtain nutrients for survival was effectively disrupted.
CBG is a powerful anti-inflammatory
One of the most prominent health benefits of cannabis is the anti-inflammatory effects. While much of this activity is the result of CBD, Other cannabinoids have been shown to cause inflammation in other ways as well Reduce.
CBG makes you hungry
People suffering from eating disorders, cachexia, anorexia or lack of appetite like side effect of cancer therapies are all common reasons for appetite to use generators.
Studies with CBD have shown that these popular cannabinoids are not alone lacks appetite-enhancing effects, but also has the opposite effect: our reduce appetite even further.
Recent studies have shown that CBG is instead a powerful one has an appetite stimulant effect.
CBG vs CBD: Main Similarities and Differences
CBG is the precursor to CBD, so it’s no surprise that the two are much show similarities.
The hemp plant uses an enzyme known as CBDA synthase to produce the structure of CBGa and convert it into CBDa.
During this process, the structure and effect profile of the molecule changes.
Controlled natural synthase of cannabinoids
It is known that every cannabis plant when it is about to flower is the first to be the CBGa produces, and from the CBGa, by means of certain enzymes, everything else cannabinoids are produced.
Due to the lack of that specific enzyme, the cannabis plant can only handle CBGa without converting the CBGa into CBDa and THCa, which means that the cannabis plant produces almost exclusively CBGa in the buds.
The CBG cannabis plants are in fact ordinary cannabis plants whose enzyme does necessary for the conversion to the other cannabinoids is missing or isolated.
If the enzyme wasn’t active in the plant, and we would enzyme during extraction, then in theory we could be the key to convert Full-Spectrum CBGa extracts into ALL other cannabinoids
I believe I have found a way to get the wild-type enzyme in dried to activate high-quality CBG cannabis, and still convert the CBGa into CBDa and THCa. During the production process I was made aware of unusual observations and surprising results.
I know our Full-Spectrum extracts are of unprecedented quality, but on that moment I was perplexed, how the hell is it possible to 0.55% CBDa in the plant to be extracted to 17.44% CBDa and 0.76% CBD in the extract, and the CBGa of 7.15% yields only a paltry 15.72% CBGa.
the percentage in the flower buds is around 17% CBGa, when there is already 1.7% CBDa and 0.07% THCa in the flower tops, there is spontaneously 1.5% THCa and 0.21% THC in the extract, this is normally not possible.
That article reads :
Cannabinoids secondary natural products from the plant Cannabis sativa L. Therapeutic cannabinoid indications are currently an important field of medicine research. We have the Δ9-tetrahydrocannabinoleic acid synthase (THCAS) and cannabidiolic acid synthase (CBDAS) recombinantly expressed in Komagataella phaffii and could be eight detecting different products with a cannabinoid scaffold after precursor conversion cannabigerolic acid (CBGA). In addition to five products yet to be identified, both enzymes formed three major cannabinoids of C. sativa – Δ 9- tetrahydrocannabinoleic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA). In the pursuit of improved enzyme properties for a biotechnological production of cannabinoids, we performed site-directed mutagenesis to determine the glycosylation pattern, the C-terminal berberine bridge enzyme (BBE) domain, active site and product specificity of examine both enzymes. The THCAS variant T_N89Q + N499Q (without two glycosylation sites) exerted about two-fold increased activity in comparison with wild type enzyme. Variant T_H494C + R532C (extra disulfide bridge) exerted an approximately 1.7- fold increased activity compared to the wild type enzyme and a shifted temperature optimum from 52 ° C to 57 ° C. We have generated two CBDAS variants, C_S116A and C_A414V, with 2.8 and 3.3-fold increased catalytic activities for CBDA production. C_A414V also showed a broadened pH spectrum and 19-fold increased catalytic activity for THCA production. These studies lay the foundation for further research and for the production of biotechnological cannabinoids. It is special to Mention is that during our extraction process, CBGa is converted into CBDa and THCa.
This information explains why CBG Bio-mass is converted into:
G5 (CBG dominant Cannabis strain)
- 7.15% CBGa
- 0.12% CBG.
- 0.55% CBDa
- <0.03% CBD.
- <0.03% THCa.
- <0.03% THC.
- 16.56% CBGa
- 2.15% CBG
- 10.98% CBDa
- 0.93% CBD.
- 0.60% THCa.
- 0.12% THC.
- 15.72% CBGa
- 1.35% CBG
- 7.44% CBDa
- 0.76% CBD
- 0.85% THCa
- 0.11% THC
Asklepios (CBG dominant Cannabis strain)
- 12.58% CBGa
- 0.35% CBG.
- 1.73% CBDa
- 0.09% CBD.
- 0.07% THCa
- <0.03% THC.
- 17.52% CBGa
- 1.94% CBG
- 11.86% CBDa
- 0.71% CBD.
- 1.50% THCa.
- 0.21% THC.
Still needs a lot of research
Obviously, it is not a normal cannabis extraction and this may be another step are in the right direction in unraveling the medicinal effect of plant-identical Full-Spectrum cannabis extracts.
That these observations raise question marks for the specialists among us is one thing certainty, I am curious about the findings of the specialists among us.
I believe that when this way of extraction can give a huge boost in producing High Quality Medicinal Full-Spectrum Cannabis Extracts, After all, we do not change anything, but activate the ” Wild Enzyme” during the extract process, which was inactive in the flowering face of the plant, and could not convert its CBGa into the other main cannabinoids CBDa, THCa and CBCa.
I can say about the extraction method that it is done with a product that is approved for the production of food supplements and cosmetics.
Time and temperatures are leading in the process.
The process has not been tampered with, 100% pure strains have been used, no cross-contamination of products and no mistakes were made during the processing.